Programmable MRI contrast switching for spatiotemporal mapping of thrombus maturation via enzyme-directed nanoprobe reconfiguration

Abstract Spatiotemporal mapping of thrombus remodeling remains a major unmet challenge due to the lack of diagnostic tools capable of dynamically converting local biochemical activity into quantitative imaging signals. Current clinical methods lack sensitivity and specificity for accurate thrombus s...

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Autori principali:	Chi Lin, Fang-Yu Hsu, Chun-Ming Shih, Tsai-Mu Cheng, Alexander T. H. Wu, Chia-Hsiung Cheng, Hsin-Ying Lu, Chun-Che Shih, Fwu-Long Mi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	SpringerOpen 2025-10-01
Serie:	Nano Convergence
Soggetti:	Programmable MRI nanoprobe MMP-responsive contrast switching Gelatin-based structural modulation Thrombus maturation mapping Targeted theranostic delivery Fucoidan
Accesso online:	https://doi.org/10.1186/s40580-025-00518-w
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