Elucidation of ACAT1's role in hepatic ischemia-reperfusion injury: TFEB-mediated mitophagy and ferroptosis modulation as therapeutic targets

Hepatic ischemia-reperfusion injury (HIRI) remains a critical clinical challenge, significantly impacting the success of liver transplantation and postoperative recovery following resection. The study investigated the roles of mitochondrial acetyl-CoA acetyltransferase1 (ACAT1) and transcription fac...

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Autors principals:	Xiangwei Li, Ting Xu, Shaochuang Wang, Long Ma, Xiangyou Yu, Yi Wang, Linlin Bai, Jun Cao, Zuyi Zhao, Meiting Du, Hao Wen, Kun Wu
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-06-01
Col·lecció:	Journal of Pharmaceutical Analysis
Matèries:	Hepatic ischemia reperfusion injury Single-cell transcriptomics Acetylproteomics Acetyl-CoA acetyltransferase 1 Transcription factor EB
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2095177925003594
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