PLAGL1 overexpression exacerbates type 1 diabetes by inducing β‐cell apoptosis via oxidative stress‐dependent dual DNA damage and cGAS/STING pathway activation

ABSTRACT Background Type 1 diabetes mellitus (T1DM) arises from autoimmune destruction of pancreatic β‐cells. Pleomorphic adenoma gene‐like 1 (PLAGL1) overexpression has been linked to β‐cell apoptosis, but molecular mechanisms remain incompletely understood. This study explored whether PLAGL1 exace...

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Hlavní autoři:	Cheng Li, Lingyan Qiao, Juan Ge, Sicui Hu, Hongxiu Yang, Conghui Hu, Tang Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-01-01
Edice:	Journal of Diabetes Investigation
Témata:	cGAS/STING PLAGL1 type 1 diabetes mellitus
On-line přístup:	https://doi.org/10.1111/jdi.70204
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