PLAGL1 overexpression exacerbates type 1 diabetes by inducing β‐cell apoptosis via oxidative stress‐dependent dual DNA damage and cGAS/STING pathway activation
ABSTRACT Background Type 1 diabetes mellitus (T1DM) arises from autoimmune destruction of pancreatic β‐cells. Pleomorphic adenoma gene‐like 1 (PLAGL1) overexpression has been linked to β‐cell apoptosis, but molecular mechanisms remain incompletely understood. This study explored whether PLAGL1 exace...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley
2026-01-01
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| Serie: | Journal of Diabetes Investigation |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1111/jdi.70204 |
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