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Combined HIF-1α blockade and CHIR99021 treatment reverses pulmonary fibrosis via modulation endothelial-to-mesenchymal transition

Summary: Radiation-induced pulmonary fibrosis (RIPF), a serious complication of radiotherapy, is characterized by HIF-1α-dependent endothelial-to-mesenchymal transition (EndMT) and persistent DNA damage. We demonstrate that the dual inhibition of HIF-1α and GSK-3β with 2-methoxyestradiol (2-ME) and...

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Principais autores: Jae-Kyung Nam, Seo-Hyun Choi, Ji-Hee Kim, Kyu Jin Choi, Hae-June Lee, Jeeyong Lee, Haeng Ran Seo, Yoon-Jin Lee
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-12-01
Serier:iScience
Fag:
Fibrosis
Molecular biology
Cell biology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004225022898
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