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C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro

Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still unknown. Antibody titers, for example, often do no...

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Principais autores: A. Robin Temming, Matthias Tammes Buirs, Arthur E. H. Bentlage, Louise W. Treffers, Hannah Feringa, Steven W. de Taeye, Taco W. Kuijpers, Sietse Q. Nagelkerke, Giso Brasser, Juk Yee Mok, Wim J. E. van Esch, Timo K. van den Berg, Theo Rispens, C. Ellen van der Schoot, Gestur Vidarsson
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-03-01
coleção:Frontiers in Immunology
Assuntos:
C-reactive protein
IgG
Fc receptor
FcγR
phagocytosis
cellular cytotoxicity
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2021.594773/full
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