Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters

A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the improvement of oral bioavailability and the feasibility of target drug delivery via oligopeptide transporters. All floxuridine 5′-amino acid monoester prodrugs exhibited PEPT1 affinity, with inhibitio...

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Bibliografische gegevens

Hoofdauteurs:	Gordon L. Amidon, Chandrasekharan Ramachandran, John M. Hilfinger, Christopher P. Landowski, Jing Sun, Balvinder S. Vig, Yasuhiro Tsume
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2008-06-01
Reeks:	Molecules
Onderwerpen:	5-FU floxuridine prodrugs Caco-2 permeability cell proliferation assays oligopeptide transporter 1 (PEPT1)
Online toegang:	http://www.mdpi.com/1420-3049/13/7/1441/
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