Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters

A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the improvement of oral bioavailability and the feasibility of target drug delivery via oligopeptide transporters. All floxuridine 5′-amino acid monoester prodrugs exhibited PEPT1 affinity, with inhibitio...

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Autori principali:	Gordon L. Amidon, Chandrasekharan Ramachandran, John M. Hilfinger, Christopher P. Landowski, Jing Sun, Balvinder S. Vig, Yasuhiro Tsume
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2008-06-01
Serie:	Molecules
Soggetti:	5-FU floxuridine prodrugs Caco-2 permeability cell proliferation assays oligopeptide transporter 1 (PEPT1)
Accesso online:	http://www.mdpi.com/1420-3049/13/7/1441/
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