Discontinuous template switching generates coronavirus subgenomic RNAs from the 3ʹ viral genome end by 5ʹ to 3ʹ transcription

ABSTRACT In coronavirus (CoV)-infected cells, several structural and accessory proteins are synthesized from subgenome RNAs (sgRNA) containing a common genomic 5ʹ-leader followed by a given open reading frame (ORF). We report that the abundance of these sgRNAs varies with distance from the 3′-end of...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ayslan Castro Brant, Zhe Hu, Angelika Zelma Chen, Vladimir Majerciak, Jonathan Yewdell, Zhi-Ming Zheng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2025-10-01
Schriftenreihe:	Journal of Virology
Schlagworte:	coronaviruses SARS-CoV-2 hCoV-OC43 COVID-19 subgenomic RNA coronavirus transcription and replication
Online-Zugang:	https://journals.asm.org/doi/10.1128/jvi.01438-25
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!