A lactylation-ferroptosis cross-talk gene signature predicts hepatocellular carcinoma prognosis and reveals STMN1/PRDX1 as therapeutic targets

IntroductionHepatocellular carcinoma (HCC) presents great difficulties for diagnosis and prognosis. Metabolic reprogramming and ferroptosis resistance play critical roles in HCC development and progression.MethodsWe combined transcriptome data from TCGA-LIHC to screen out lactylation-ferroptosis-rel...

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Главные авторы:	Jiali Meng, Chunyan Liang, Ling Li, Qiqi Huang, Weimei Huang, Rensheng Wang, Xiaolong Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2025-12-01
Серии:	Frontiers in Immunology
Предметы:	hepatocellular carcinoma (HCC) lactylation ferroptosis prognostic analysis early-stage biomarkers
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1677089/full
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