HDAC2 as a therapeutic target in bladder cancer: insights into the altered epigenetic regulation and lysine lactylation

Abstract Background The pathogenesis of bladder cancer (BCa) is driven in part by aberrant epigenetic regulation, most notably the dysregulated expression of histone deacetylases (HDACs). As a class I HDAC, HDAC2 is often overexpressed in cancers and promotes malignancy through diverse mechanisms. G...

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Hlavní autoři:	Guanghui Xu, Shuo Liang, Ganlin Hu, Wei Zhao, Yuqin Li, Minghao Zheng, Zhigang Wu, Tianlei Xie, Shuting Fang, Shan Peng, Yongming Deng, Yihua Zhou, Hongqian Guo, Junlong Zhuang, Wenli Diao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-12-01
Edice:	Journal of Experimental & Clinical Cancer Research
Témata:	Bladder cancer Epigenetic regulation HDAC2 Post-translational modifications Lactylation
On-line přístup:	https://doi.org/10.1186/s13046-025-03610-5
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