Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling

By recognizing double-stranded RNA, RIG-I is implicated in anti-viral immune responses, but also in cancer development and intestinal inflammation. Here the authors identify frameshift germline mutations of RIG-I, resulting in the generation of a circular RNA associated with increased susceptibility...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Jia Song, Wei Zhao, Xin Zhang, Wenyu Tian, Xuyang Zhao, Liang Ma, Yongtong Cao, Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2022-11-01
Sarja:	Nature Communications
Linkit:	https://doi.org/10.1038/s41467-022-34885-3
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