Genetically instrumented circulating metabolites and hepatobiliary cancer risk: A multi-tiered Mendelian randomization and functional interrogation

BackgroundHepatobiliary malignancies—including hepatocellular carcinoma and cholangiocarcinoma—are major causes of cancer-related mortality worldwide, yet their regulatory pathways remain incompletely defined.MethodsWe employed a two-sample Mendelian randomization (MR) approach to systematically inv...

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Autores principales:	Lin Tuo, Li Ting Yan, Ying Liu, Shu Qiang Wang, Xing Xiang Yang, Xiang An
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-10-01
Colección:	Frontiers in Oncology
Materias:	circulating metabolites multivariable mendelian randomization analysis hepatobiliary malignancies 4-hydroxyhippurate 3-hydroxyisobutyrate
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1680865/full
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