Genetically instrumented circulating metabolites and hepatobiliary cancer risk: A multi-tiered Mendelian randomization and functional interrogation

BackgroundHepatobiliary malignancies—including hepatocellular carcinoma and cholangiocarcinoma—are major causes of cancer-related mortality worldwide, yet their regulatory pathways remain incompletely defined.MethodsWe employed a two-sample Mendelian randomization (MR) approach to systematically inv...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Lin Tuo, Li Ting Yan, Ying Liu, Shu Qiang Wang, Xing Xiang Yang, Xiang An
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2025-10-01
سلاسل:	Frontiers in Oncology
الموضوعات:	circulating metabolites multivariable mendelian randomization analysis hepatobiliary malignancies 4-hydroxyhippurate 3-hydroxyisobutyrate
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1680865/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!