HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis

Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans in vivo. While HIVEP1 is known to interact with NF-ĸB binding DNA motifs, its function in mammalian cells is unknown. We report increased...

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主要な著者:	Hisatake Matsumoto, Brendon P. Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gürkan, Erik Malmström, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van ‘t Veer, Tom van der Poll
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2021-11-01
シリーズ:	Frontiers in Immunology
主題:	HIVEP MyD88 NF-κB sepsis toll-like receptors
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.744358/full
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