Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC−/−) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic component of gram-negative bacteria. Here, we investig...

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Principais autores:	Mariska T. Meijer, Alex F. de Vos, Brendon P. Scicluna, Joris J. Roelofs, Chérine Abou Fayçal, Gertraud Orend, Fabrice Uhel, Tom van der Poll
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-03-01
coleção:	Frontiers in Immunology
Assuntos:	tenascin C sepsis Klebsiella pneumoniae (K. pneumoniae) pneumonia alarmins innate immunity
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.600979/full
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