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Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

Abstract Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelination. Microglia play a pivotal role in regulating...

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Principais autores: Nicolau Beckmann, Elisa Giorgetti, Anna Neuhaus, Stefan Zurbruegg, Nathalie Accart, Paul Smith, Julien Perdoux, Ludovic Perrot, Mark Nash, Sandrine Desrayaud, Peter Wipfli, Wilfried Frieauff, Derya R. Shimshek
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2018-02-01
Series:Acta Neuropathologica Communications
Assuntos:
Neuroinflammation
Microglia
Astrocyte
Cuprizone
Myelination
Multiple sclerosis
Acceso en liña:http://link.springer.com/article/10.1186/s40478-018-0510-8
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