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Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Abstract Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis. Despite the extensive use of cuprizone, the mechanism by which it induces demyelination are still...

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Principais autores: Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew V. Caprariello, Jason R. Plemel
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2022-05-01
סדרה:Molecular Neurodegeneration
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גישה מקוונת:https://doi.org/10.1186/s13024-022-00538-8
תגים: הוספת תג
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