ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatocellular cancer. This study investigated whether ETV4, ALYREF, and PKM2 affect glycolytic metabolism and ferroptosis, thereby potentially influencing ICC. Methods Bioinformatic analysis was used to expl...

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Detalles Bibliográficos

Autores principales:	Xiaohui Wang, Wenbin Duan, Zhongzhi Ma, Haoquan Wen, Xianhai Mao, Changjun Liu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-04-01
Colección:	Cancer & Metabolism
Materias:	ICC PKM2 ETV4 ALYREF Glycolytic metabolism Ferroptosis
Acceso en línea:	https://doi.org/10.1186/s40170-025-00387-1
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