The role of extracellular matrix stiffness in regulating fibroblast behaviors and disease progression

As a representative physical factor in the extracellular matrix (ECM), ECM stiffness regulates fibroblast behaviors and contributes to physiological homeostasis and pathological processes. This process relies on mechanosensors, including integrin-based adhesion complexes, mechanosensitive ion channe...

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Autores principales:	Zezhi Fan, Kaiyuan Deng, Lin Wang, Jiangjiang Fu, Li Ma, Shiwei Tu, Junyi Li, Kaifang Yao, Zhifang Xu, Yi Guo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-06-01
Colección:	Frontiers in Immunology
Materias:	extracellular matrix stiffness fibroblasts fibrosis mechanotransduction tumors
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1849447/full
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