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Detection and characterization of eravacycline heteroresistance in clinical bacterial isolates

Eravacycline (ERV) has emerged as a therapeutic option for the treatment of carbapenem-resistant pathogens. However, the advent of heteroresistance (HR) to ERV poses a challenge to these therapeutic strategies. This study aimed to investigate ERV HR prevalence among common clinical isolates and furt...

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Autori principali: Yingfeng Zhang, Dongdong Liu, Yongzhu Liu, Qiwei Li, Hongwei Liu, Peng Zhou, Yaqin Liu, Lili Chen, Weiguo Yin, Yang Lu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-03-01
Serie:Frontiers in Microbiology
Soggetti:
eravacycline
heteroresistance
carbapenem-resistant Klebsiella pneumoniae
whole-genome sequencing
time-killing assay
fitness cost
Accesso online:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1332458/full
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