Malaria pigment hemozoin drives M1 pro-inflammatory macrophage polarization in vitro

Abstract Severe malaria, a high burden parasitic disease, is characterized by hyperproduction of proinflammatory cytokines, most likely generated by M1-polarized macrophages. Malaria pigment or hemozoin (HZ), a byproduct of heme detoxification in intra-erythrocytic parasites, is internalized by circ...

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Hlavní autoři:	Federica Perego, Silvia Parapini, Estefanía Calvo-Alvarez, Maria Dolci, Serena Delbue, Silvia Ghezzi, Elisa Vicenzi, Guido Poli, Nicoletta Basilico, Sarah D’Alessandro
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-12-01
Edice:	Scientific Reports
Témata:	Malaria Hemozoin (HZ) Malaria pigment Innate immunity Macrophage polarization
On-line přístup:	https://doi.org/10.1038/s41598-025-30231-x
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