Malaria pigment hemozoin drives M1 pro-inflammatory macrophage polarization in vitro
Abstract Severe malaria, a high burden parasitic disease, is characterized by hyperproduction of proinflammatory cytokines, most likely generated by M1-polarized macrophages. Malaria pigment or hemozoin (HZ), a byproduct of heme detoxification in intra-erythrocytic parasites, is internalized by circ...
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| Principais autores: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Portfolio
2025-12-01
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| Serija: | Scientific Reports |
| Teme: | |
| Online dostop: | https://doi.org/10.1038/s41598-025-30231-x |
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