Identification of Novel Inhibitors of <i>Escherichia coli</i> DNA Ligase (LigA)

Present in all organisms, DNA ligases catalyse the formation of a phosphodiester bond between a 3′ hydroxyl and a 5′ phosphate, a reaction that is essential for maintaining genome integrity during replication and repair. Eubacterial DNA ligases use NAD⁺ as a cofactor and possess low seque...

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Principais autores:	Arqam Alomari, Robert Gowland, Callum Southwood, Jak Barrow, Zoe Bentley, Jashel Calvin-Nelson, Alice Kaminski, Matthew LeFevre, Anastasia J. Callaghan, Helen A. Vincent, Darren M. Gowers
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2021-04-01
叢編:	Molecules
主題:	antibacterial target chemical inhibitors DNA ligase molecular docking NAD<sup>+</sup>-dependent
在線閱讀:	https://www.mdpi.com/1420-3049/26/9/2508
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