Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

A hypothesis that simultaneous targeting cancer-related carbonic anhydrase hCA IX and hCA XII isoforms (whose overexpression is a cancer cell’s defence mechanism against hypoxia) along with thioredoxin reductase (overexpressed in cancers as a defence against oxidative stress) may lead to synergistic...

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Bibliografiske detaljer

Principais autores:	Mikhail Krasavin, Tatiana Sharonova, Vladimir Sharoyko, Daniil Zhukovsky, Stanislav Kalinin, Raivis Žalubovskis, Tatiana Tennikova, Claudiu T. Supuran
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis Group 2020-01-01
Serier:	Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:	anticancer agents carbonic anhydrase inhibition thioredoxin reductase inhibition synergistic effect dual pharmacophores michael acceptors zinc-binding group hypoxia oxidative stress cancer cell defence mechanisms
Online adgang:	http://dx.doi.org/10.1080/14756366.2020.1734800
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