The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c

Mycobacterium tuberculosis bifunctional enzyme GlmU is a novel target for anti-TB drugs and is involved in glycosyl donor UDP-N-acetylglucosamine biosynthesis. Here, we found that TPSA (2-[5-(2-{[4-(2-thienyl)-2-pyrimidinyl]sulfanyl}acetyl)-2-thienyl]acetic acid) was a novel inhibitor for GlmU acety...

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Principais autores:	Changming Chen, Xiuyan Han, Qiulong Yan, Chao Wang, Liqiu Jia, Ayaz Taj, Lizhe Zhao, Yufang Ma
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2019-07-01
Series:	Frontiers in Cellular and Infection Microbiology
Assuntos:	Mycobacteria tuberculosis UDP-GlcNAc GlmU acetyltransferase inhibitor methyltransferases
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fcimb.2019.00251/full
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