FGF/FGFR1,2 targeting can attenuate lung parenchymal and vascular remodeling: an opportunity for drug repurposing against chronic lung disease and post COVID‐19 sequelae

Abstract Purpose The fibroblast growth factor and its receptors (FGF/FGFR-1,2) are expressed in lung mesenchyme and vasculature in chronic lung diseases (DPLD). They form complexes with ECM, vessels and fine-tune epithelial/endothelial cell proliferation and regeneration. Therefore they may prove to...

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Prif Awduron:	R. Kulshrestha, M. Rani, R. Dahiya, A. Singh, S. Doraiswamy, S. Bharadwaj, J. Batra, P. Kumar, A. Pandey, A. K. Dinda, R. Krishnan, A. K. Mishra
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-09-01
Cyfres:	Surgical and Experimental Pathology
Pynciau:	BFGF FGFR-1,2 Parenchymal and vascular remodeling Lung fibrosis Repurposing Sildenafil and bosentan
Mynediad Ar-lein:	https://doi.org/10.1186/s42047-025-00202-7
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