Dilated cardiomyopathy mutation (R134W) in mouse cardiac troponin T induces greater contractile deficits against α-myosin heavy chain than against β-myosin heavy chain

Many studies have demonstrated that depressed myofilament Ca2+ sensitivity is common to dilated cardiomyopathy (DCM) in humans. However, it remains unclear whether a single determinant — such as myofilament Ca2+ sensitivity — is sufficient to characterize all cases of DCM because the severity of di...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Sampath K Gollapudi, Murali Chandra
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2016-10-01
Edice:	Frontiers in Physiology
Témata:	Troponin T myosin heavy chain dilated cardiomyopathy contractile dynamics thin filament function myofilament cooperativity
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00443/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!