Dilated cardiomyopathy mutation (R134W) in mouse cardiac troponin T induces greater contractile deficits against α-myosin heavy chain than against β-myosin heavy chain

Many studies have demonstrated that depressed myofilament Ca2+ sensitivity is common to dilated cardiomyopathy (DCM) in humans. However, it remains unclear whether a single determinant — such as myofilament Ca2+ sensitivity — is sufficient to characterize all cases of DCM because the severity of di...

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Autors principals:	Sampath K Gollapudi, Murali Chandra
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2016-10-01
Col·lecció:	Frontiers in Physiology
Matèries:	Troponin T myosin heavy chain dilated cardiomyopathy contractile dynamics thin filament function myofilament cooperativity
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00443/full
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