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T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells

T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK cells and failure to control tumor growth. In contrast to mice, the current knowledge on the role of...

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Detalhes bibliográficos
Principais autores: Laura Kiekens, Wouter Van Loocke, Sylvie Taveirne, Sigrid Wahlen, Eva Persyn, Els Van Ammel, Zenzi De Vos, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Pieter Van Vlierberghe, Bart Vandekerckhove, Georges Leclercq
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-09-01
coleção:Frontiers in Immunology
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Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2021.732511/full
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