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T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells

T-bet and Eomes are transcription factors that are known to be important in maturation and function of murine natural killer (NK) cells. Reduced T-BET and EOMES expression results in dysfunctional NK cells and failure to control tumor growth. In contrast to mice, the current knowledge on the role of...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Laura Kiekens, Wouter Van Loocke, Sylvie Taveirne, Sigrid Wahlen, Eva Persyn, Els Van Ammel, Zenzi De Vos, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Pieter Van Vlierberghe, Bart Vandekerckhove, Georges Leclercq
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021-09-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
human NK cells
transcription factors
T-BET
EOMES
CD16 expression
antibody-dependent cellular cytotoxicity
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.732511/full
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