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Control of Spontaneous HPV16 E6/E7 Expressing Oral Cancer in HLA-A2 (AAD) Transgenic Mice with Therapeutic HPV DNA Vaccine

Abstract Background Human Papillomavirus type 16 (HPV16) has been associated with a subset of head and neck cancers. Two HPV encoded oncogenic proteins, E6 and E7, are important for the malignant progression of HPV-associated cancers. A spontaneous HPV16 E6/E7-expressing oral tumor model in human HL...

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Principais autores: Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung, T. -C. Wu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-09-01
coleção:Journal of Biomedical Science
Assuntos:
HPV
DNA vaccine
Preclinical model
HPV16
Transgenic mice
HLA-A2
Acesso em linha:https://doi.org/10.1186/s12929-021-00759-x
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