Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment

Malaria remains a major public health problem worldwide, including in Southeast Asia. Chemotherapeutic agents such as chloroquine (CQ) are effective, but problems with drug resistance and toxicity have necessitated a continuous search for new effective antimalarial agents. Here we report on a virtua...

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Автори:	Amirah Hani Ramli, Puspanjali Swain, Muhammad Syafiq Akmal Mohd Fahmi, Faridah Abas, Sze Wei Leong, Bimo Ario Tejo, Khozirah Shaari, Amatul Hamizah Ali, Hani Kartini Agustar, Rusdam Awang, Yee Ling Ng, Yee Ling Lau, Mohammad Aidiel Md Razali, Siti Nurulhuda Mastuki, Norazlan Mohmad Misnan, Siti Munirah Mohd Faudzi, Cheol-Hee Kim
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2024-03-01
Серія:	Heliyon
Предмети:	Diarylpentanoids Molecular docking Antimalarial activity PfLDH inhibitors Zebrafish
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S2405844024034935
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