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Synthesis and anti-inflammatory activity of benzimidazole derivatives; an in vitro, in vivo and in silico approach

Many non-steroidal anti-inflammatory drugs (NSAIDs) concurrently inhibit both COX-1 and COX-2, with a preference for specifically targeting COX-2 due to its significant involvement in various pathologies. In addition to COX enzymes, several other targets, including Aldose reductase, Aldo-ketoreducta...

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Principais autores: Shaher Bano, Humaira Nadeem, Iqra Zulfiqar, Tamseela Shahzadi, Tayyaba Anwar, Asma Bukhari, Syed Muzzammil Masaud
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-05-01
Serier:Heliyon
Fag:
Benzimidazole derivatives
Anti-inflammatory activity
Computational studies
COX
Aldose reductase
Phospholipase A2
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024061334
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