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APOL1 plasma membrane pools resist rapid protein degradation

Abstract Homozygosity of two sequence variants within the human APOL1 gene, called APOL1 G1 and G2, in combination with high Apolipoprotein L1 (APOL1) expression levels are linked to a wide spectrum of renal diseases summarized as APOL1-mediated kidney diseases (AMKDs). Previous studies have shown t...

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Gardado en:
Principais autores: Verena Höffken, Laura Alvermann, David Niggemeier, Katrin Beul, Pavel Nedvetsky, Bernhard Ellinger, Daria Assenmacher, Daniel Granado, Hermann Pavenstädt, Thomas Weide
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2026-02-01
Series:Scientific Reports
Assuntos:
APOL1
APOL2
AMKD
Degradation
Renal risk variants
surface-localized pools
Acceso en liña:https://doi.org/10.1038/s41598-026-37647-z
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