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Identification of Transcriptomic Differences in Induced Pluripotent Stem Cells and Neural Progenitors from Amyotrophic Lateral Sclerosis Patients Carrying Different Mutations: A Pilot Study

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting motor neurons with a phenotypic and genetic heterogeneity and elusive molecular mechanisms. With the present pilot study, we investigated different genetic mutations (<i>C9orf72</i>, <i>TARDBP</i>, and <i>KIF5A<...

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Principais autores: Chiara Sgromo, Martina Tosi, Cristina Olgasi, Fabiola De Marchi, Francesco Favero, Giorgia Venturin, Beatrice Piola, Alessia Cucci, Lucia Corrado, Letizia Mazzini, Sandra D’Alfonso, Antonia Follenzi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-06-01
Serier:Cells
Fag:
Amyotrophic lateral sclerosis
induced pluripotent stem cells
transcriptomic analysis
RNA-seq
neural progenitor cells
Online adgang:https://www.mdpi.com/2073-4409/14/13/958
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