PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

ABSTRACT Clear cell renal cell carcinoma (ccRCC) is characterized by aberrant lipid droplet (LD) accumulation, which promotes tumor progression and sunitinib resistance. However, the underlying molecular mechanisms remain incompletely understood. This study shows that reduced PDZK1 expression correl...

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Principais autores:	Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-04-01
Series:	Advanced Science
Assuntos:	lipophagy PDZK1 sunitinib resistance therapeutic targeting ULK1
Acceso en liña:	https://doi.org/10.1002/advs.202511606
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