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Muribaculum intestinale alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization

Abstract Background Gut microbiota dysbiosis has been implicated in the pathogenesis of depression. Our previous studies identified loganin as a potential antidepressant agent; however, its oral bioavailability is low. Whether loganin alleviates depression via modulation of the gut microbiota remain...

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Principais autores: Jun He, Man-Ni Wang, Hong-Jin Chen, Guo-Yan Zuo, Jing-Liang Li, Wei-Feng Yin, Xue-Ge Pan, Yung-Chi Cheng, Cong-Yuan Xia, Jie-Kun Xu, Wei-Ku Zhang
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-03-01
Series:Microbiome
Assuntos:
Loganin
Muribaculum intestinale
Gut microbiome
Depression
Th17 cells
Microglia
Acceso en liña:https://doi.org/10.1186/s40168-026-02354-4
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