Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition

Abstract Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases. However, the rapid development of menin inhibitor resistance calls for combinatory strategies to improve responses and...

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Autors principals:	Xiangguo Shi, Minhua Li, Zian Liu, Jonathan Tiessen, Yuan Li, Jing Zhou, Yudan Zhu, Swetha Mahesula, Qing Ding, Lin Tan, Mengdie Feng, Yuki Kageyama, Yusuke Hara, Jacob J. Tao, Xuan Luo, Kathryn A. Patras, Philip L. Lorenzi, Suming Huang, Alexandra M. Stevens, Koichi Takahashi, Ghayas C. Issa, Md. Abul Hassan Samee, Michalis Agathocleous, Daisuke Nakada
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-03-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-57544-9
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