Macrophage metabolic reprogramming via HIF-1α–glycolysis drives osteoblast ferroptosis and bone loss through an IL-6–STAT3–dependent redox axis

Background Postmenopausal osteoporosis (PMOP) is characterized by exacerbated bone resorption and inadequate bone formation, with macrophage-driven inflammation playing a key role. However, how immunometabolic reprogramming of macrophages modulates osteoblast fate remains unknown.Methods Using integ...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Yifan Gu, Kun Wang, Yicong Wang, Ziru Wang, Yiheng Li, Lei Li, Shuai Jiang, Yu Zheng, Run Feng, Min Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2026-12-01
Serie:	Redox Report
Soggetti:	Osteoporosis immunometabolism ferroptosis HIF-1α glycolysis macrophage polarization
Accesso online:	https://www.tandfonline.com/doi/10.1080/13510002.2026.2667673
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!