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Macrophage metabolic reprogramming via HIF-1α–glycolysis drives osteoblast ferroptosis and bone loss through an IL-6–STAT3–dependent redox axis

Background Postmenopausal osteoporosis (PMOP) is characterized by exacerbated bone resorption and inadequate bone formation, with macrophage-driven inflammation playing a key role. However, how immunometabolic reprogramming of macrophages modulates osteoblast fate remains unknown.Methods Using integ...

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Principais autores: Yifan Gu, Kun Wang, Yicong Wang, Ziru Wang, Yiheng Li, Lei Li, Shuai Jiang, Yu Zheng, Run Feng, Min Yang
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2026-12-01
Serier:Redox Report
Fag:
Osteoporosis
immunometabolism
ferroptosis
HIF-1α
glycolysis
macrophage polarization
Online adgang:https://www.tandfonline.com/doi/10.1080/13510002.2026.2667673
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