Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region
In vivo clinical applications of nanobodies (VHHs) require molecules that induce minimal immunoresponse and therefore possess sequences as similar as possible to the human VH domain. Although the relative sequence variability in llama nanobodies has been used to identify scaffolds with partially hum...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
MDPI AG
2021-01-01
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| Reeks: | Biomolecules |
| Onderwerpen: | |
| Online toegang: | https://www.mdpi.com/2218-273X/11/2/163 |
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