Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region

In vivo clinical applications of nanobodies (VHHs) require molecules that induce minimal immunoresponse and therefore possess sequences as similar as possible to the human VH domain. Although the relative sequence variability in llama nanobodies has been used to identify scaffolds with partially hum...

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Detalhes bibliográficos

Principais autores:	Miguel A. Soler, Barbara Medagli, Jiewen Wang, Sandra Oloketuyi, Gregor Bajc, He Huang, Sara Fortuna, Ario de Marco
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-01-01
Colecção:	Biomolecules
Assuntos:	nanobody framework modeling nanobody humanization CDR grafting
Acesso em linha:	https://www.mdpi.com/2218-273X/11/2/163
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