CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets

Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of Tregs is being clinically evaluated as a novel way to prevent or treat T1D. Genetic modification of Tregs, most notab...

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Bibliografiske detaljer

Principais autores:	Xiangni Wu, Pin-I Chen, Robert L. Whitener, Matthew S. MacDougall, Vy M. N. Coykendall, Hao Yan, Yong Bin Kim, William Harper, Shiva Pathak, Bettina P. Iliopoulou, Allison Hestor, Diane C. Saunders, Erick Spears, Jean Sévigny, David M. Maahs, Marina Basina, Seth A. Sharp, Anna L. Gloyn, Alvin C. Powers, Seung K. Kim, Kent P. Jensen, Everett H. Meyer
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2024-06-01
Serier:	Frontiers in Immunology
Fag:	Treg-regulatory T cell chimeric antigen receptor type 1 diabetes immunoregulation cytotoxicity
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1415102/full
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