Hemagglutinin Protease HapA Associated With Vibrio cholerae Outer Membrane Vesicles (OMVs) Disrupts Tight and Adherens Junctions

ABSTRACT This study explores the virulence mechanisms of Vibrio cholerae, with a particular emphasis on HapA, a zinc metalloprotease delivered via outer membrane vesicles (OMVs). The findings reveal that OMV‐associated HapA disrupts the integrity of tight and adherens junctions in intestinal epithel...

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Detalhes bibliográficos
Main Authors: Palwasha Baryalai, David Irenaeus, Eric Toh, Madeleine Ramstedt, Bernt Eric Uhlin, Aftab Nadeem, Sun Nyunt Wai
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-05-01
Colecção:Journal of Extracellular Vesicles
Assuntos:
adherens junctions
cholera
outer membrane vesicles
protease
tight junctions
virulence
Acesso em linha:https://doi.org/10.1002/jev2.70092
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