Liquidambaric acid as a non-competitive α-glucosidase inhibitor: multi-level evidence from enzyme kinetics, molecular docking, molecular dynamics simulations, and a Drosophila hyperglycaemic model

Liquidambaric acid, a pentacyclic triterpenoid from Liquidambar formosana Hance, was evaluated as a novel α-glucosidase inhibitor for type 2 diabetes mellitus (T2DM) management. Enzyme kinetic assays revealed its potent non-competitive inhibition (IC50 = 0.12 mM). Molecular docking showed stable hyd...

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Egile Nagusiak:	Liwei Jia, Yan Liu, Bo Fu, Yuan Tian, Xin Meng
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Taylor & Francis Group 2025-12-01
Saila:	Journal of Enzyme Inhibition and Medicinal Chemistry
Gaiak:	Liquidambaric acid α-glucosidase type 2 diabetes mellitus enzyme kinetics Drosophila melanogaster
Sarrera elektronikoa:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2497486
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