Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

Tissue factor is highly expressed in sub-endothelial tissue. The extracellular allosteric disulfide bond Cys186-Cys209 of human tissue factor shows high evolutionary conservation and in vitro evidence suggests that it significantly contributes to tissue factor procoagulant activity. To investigate...

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Autors principals:	Susanna H. M. Sluka, Simon F. Stämpfli, Alexander Akhmedov, Tanja Klein-Rodewald, Adrián Sanz-Moreno, Marion Horsch, Paula Grest, Andrea S. Rothmeier, Birgit Rathkolb, Anja Schrewe, Johannes Beckers, Frauke Neff, Eckhard Wolf, Giovanni G. Camici, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Thomas F. Lüscher, Wolfram Ruf, Felix C. Tanner
Format:	Artigo
Idioma:	Inglês
Publicat:	Ferrata Storti Foundation 2019-09-01
Col·lecció:	Haematologica
Accés en línia:	https://haematologica.org/article/view/9553
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