Structures of TRPV1 bound by hyperthermia-inducing analgesics

Summary: TRPV1, a member of the transient receptor potential vanilloid subfamily, mediates nociception and thermoregulation. TRPV1-targeting analgesics frequently induce hyperthermia, underscoring the need for structural insights to guide the development of safer compounds. Here, we determined the s...

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Bibliografiske detaljer

Principais autores:	Yu-Hao Gao, Yi-Zhe Huang, Zhao-Xing Li, Xiao-Ying Chen, Chang-Yan Shao, Han-Wen Li, Bin Liu, Fán Yang, Mei-Rong Chen, Mei-Ling Lu, Michael X. Zhu, Fan Yang, Yi-Bei Xiao, Ye Yu
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2026-01-01
Serier:	Cell Reports
Fag:	CP: Neuroscience
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124725015372
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