Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures

Summary: Tumor hypoxia drives metabolic shifts, cancer progression, and therapeutic resistance. Challenges in quantifying hypoxia have hindered the exploitation of this potential “Achilles’ heel.” While gene expression signatures have shown promise as surrogate measures of hypoxia, signature usage i...

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Principais autores:	Matteo Di Giovannantonio, Fiona Hartley, Badran Elshenawy, Alessandro Barberis, Dan Hudson, Hana S. Shafique, Vincent E.S. Allott, David A. Harris, Simon R. Lord, Syed Haider, Adrian L. Harris, Francesca M. Buffa, Benjamin H.L. Harris
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2025-02-01
叢編:	Cell Genomics
主題:	hypoxia tumorigenesis biomarkers transcriptomics gene signature signature scores
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2666979X25000205
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