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Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures

Summary: Tumor hypoxia drives metabolic shifts, cancer progression, and therapeutic resistance. Challenges in quantifying hypoxia have hindered the exploitation of this potential “Achilles’ heel.” While gene expression signatures have shown promise as surrogate measures of hypoxia, signature usage i...

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Principais autores: Matteo Di Giovannantonio, Fiona Hartley, Badran Elshenawy, Alessandro Barberis, Dan Hudson, Hana S. Shafique, Vincent E.S. Allott, David A. Harris, Simon R. Lord, Syed Haider, Adrian L. Harris, Francesca M. Buffa, Benjamin H.L. Harris
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-02-01
Colecção:Cell Genomics
Assuntos:
hypoxia
tumorigenesis
biomarkers
transcriptomics
gene signature
signature scores
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666979X25000205
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